Circadian rhythms in colonic function

Frontiers in Physiology

Physiology

Vladimir P. Zagorodnyuk¹  Stewart Ramsay¹  Timothy J. Hibberd¹  Phaedra Spencer-Merris¹  Nick J. Spencer¹  Phil G. Dinning² 

[1] College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;Colorectal Surgical Unit, Division of Surgery, Flinders Medical Centre, Adelaide, SA, Australia;

关键词: colon;    circadian rhythms;    colonic motility;    enteric nervous system;    time of day;    pain signaling;    colonic absorption;    colonic manometry;   

DOI  :  10.3389/fphys.2023.1239278

 received in 2023-06-13, accepted in 2023-08-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues throughout the body, termed “peripheral clocks.” Peripheral clocks are subject to entrainment by a multitude of factors, many of which are directly or indirectly controlled by the light-entrainable clock located in the suprachiasmatic nucleus of the hypothalamus. Peripheral clocks occur in the gastrointestinal tract, notably the epithelia whose functions include regulation of absorption, permeability, and secretion of hormones; and in the myenteric plexus, which is the intrinsic neural network principally responsible for the coordination of muscular activity in the gut. This review focuses on the physiological circadian variation of major colonic functions and their entraining mechanisms, including colonic motility, absorption, hormone secretion, permeability, and pain signalling. Pathophysiological states such as irritable bowel syndrome and ulcerative colitis and their interactions with circadian rhythmicity are also described. Finally, the classic circadian hormone melatonin is discussed, which is expressed in the gut in greater quantities than the pineal gland, and whose exogenous use has been of therapeutic interest in treating colonic pathophysiological states, including those exacerbated by chronic circadian disruption.

【 授权许可】

Unknown   
Copyright © 2023 Hibberd, Ramsay, Spencer-Merris, Dinning, Zagorodnyuk and Spencer.