VEGF-A related SNPs: a cardiovascular context

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

B. R. Palmer¹  C. Bromhead²  J. C. Meza-Alvarado²  R. A. Page²  B. Mallard² 

[1] Correspondence:;School of Health Sciences, Massey University, Wellington, New Zealand;

关键词: vascular endothelial growth factor;    single nucleotide polymorphism;    cardiovascular disease;    VEGF-A eQTLs;    genetic association;   

DOI  :  10.3389/fcvm.2023.1190513

 received in 2023-03-29, accepted in 2023-04-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Currently, cardiovascular disease risk algorithms play a role in primary prevention. However, this is complicated by a lack of powerfully predictive biomarkers that could be observed in individuals before the onset of overt symptoms. A key potential biomarker for heart disease is the vascular endothelial growth factor (VEGF-A), a molecule that plays a pivotal role in blood vessel formation. This molecule has a complex biological role in the cardiovascular system due to the processes it influences, and its production is impacted by various CVD risk factors. Research in different populations has shown single nucleotide polymorphisms (SNPs) may affect circulating VEGF-A plasma levels, with some variants associated with the development of CVDs, as well as CVD risk factors. This minireview aims to give an overview of the VEGF family, and of the SNPs reported to influence VEGF-A levels, cardiovascular disease, and other risk factors used in CVD risk assessments.

【 授权许可】

Unknown   
© 2023 Meza-Alvarado, Page, Mallard, Bromhead and Palmer.