Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, are they markers of COVID-19 severity or old age and frailty? A comparison of two distinct cohorts

Frontiers in Medicine

Medicine

Yochai Levy¹  Estela Derazne²  Ilia Stambler²  Nadya Kagansky³  Dana Kagansky⁴  Alex Shilovsky⁵  Evelina Mazurez⁵  Alex Derkath⁵  Victor Chepelev⁵ 

[1] Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel;Sackler School of Medicine, Tel Aviv, Israel;Sackler School of Medicine, Tel Aviv, Israel;Sackler School of Medicine, Tel Aviv, Israel;Shmuel Harofe Geriatric Medical Center, Be'er Ya'akov, Israel;Shamir Medical Center, Zerifin, Israel;Shmuel Harofe Geriatric Medical Center, Be'er Ya'akov, Israel;

关键词: nursing homes;    geriatric;    frailty;    old age;    COVID-19;    neutrophil to lymphocyte ratio;    platelet to lymphocyte ratio;   

DOI  :  10.3389/fmed.2023.1222692

 received in 2023-05-15, accepted in 2023-06-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are simple markers of systemic inflammatory responses. It has been previously suggested that they can predict COVID-19 severity. Age and frailty may also influence their values. This study aimed to evaluate the impact of COVID-19 severity versus age and frailty on NLR and PLR values. This was a retrospective, observational two cohorts’ comparative study. The first cohort is comprised of patents positive for SARS-CoV-2, with mild or asymptomatic disease, admitted to designated COVID-19 departments in a large geriatric medical center (GMC). The second included patients with COVID-19 admitted to designated COVID-19 departments in a large general hospital for symptomatic disease from March 2020 to March 2021. We compared baseline characteristics including comorbidities and chronic medications, disease symptoms, laboratory tests and compared the NLR and PLR between the two groups. The 177 patients admitted to the COVID-designated department in the GMC were over three decades older than the 289 COVID-19 patients admitted to the general hospital care (HC). They had substantially more comorbidities and chronic medications. All common disease symptoms were significantly more common in the HC group. Almost two thirds of the GMC patients remained asymptomatic compared to 2.1% in the HC group. Inflammatory markers, such as CRP and LDH, were significantly higher in the HC group. The NLR and PLR were both significantly higher in the GMC cohort comprised of older frailer patients with milder disease. NLR and PLR seem to be affected more by age and frailty than COVID-19 severity.

【 授权许可】

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Copyright © 2023 Levy, Derazne, Shilovsky, Kagansky, Derkath, Chepelev, Mazurez, Stambler and Kagansky.