Changes in the autonomic cardiorespiratory activity in parturient women with severe and moderate features of preeclampsia

Frontiers in Immunology

Immunology

Miguel Ángel Peña-Castillo¹  Yecid Mina-Paz²  Ejay Nsugbe³  Miguel Ángel Porta-García⁴  José Javier Reyes-Lagos⁴  Claudia Ivette Ledesma-Ramírez⁴  Elias Yojairi Pichardo-Carmona⁴  Rosselin Gabriela Ceballos-Juárez⁴  Hugo Mendieta-Zerón⁵ 

[1]Basic Sciences and Engineering Division, Metropolitan Autonomous University (UAM-I), Iztapalapa, Mexico

[2]Faculty of Health Sciences, Universidad Libre Seccional Cali, Cali, Colombia

[3]Nsugbe Research Labs, Swindon, United Kingdom

[4]School of Medicine, Autonomous University of the State of Mexico (UAEMéx), Toluca, Mexico

[5]School of Medicine, Autonomous University of the State of Mexico (UAEMéx), Toluca, Mexico

[6]Mónica Pretelini Sáenz Maternal-Perinatal Hospital, Health Institute of the State of Mexico (ISEM), Toluca, Mexico

关键词: vagal withdrawal;    mutual information;    pregnancy;    cardiorespiratory coupling;    pulse-respiration quotient;   

DOI  :  10.3389/fimmu.2023.1190699

 received in 2023-03-21, accepted in 2023-08-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundCardiorespiratory coupling (CRC) is a physiological phenomenon that reflects the mutual interaction between the cardiac and respiratory control systems. It is mainly associated with efferent vagal activity from the central autonomic network. Few studies have explored the autonomic changes of CRC in preeclampsia, a critical obstetric complication related to possible autonomic dysfunctions and inflammatory disturbances. This study examined the autonomic mechanisms of CRC in women with severe and moderate preeclampsia and healthy controls by applying nonlinear methods based on information theory, such as mutual information (MI) and Renyi’s mutual information (RMI) and the linear and nonlinear analysis of the Pulse-Respiration Quotient (PRQ).MethodsWe studied three groups of parturient women in the third trimester of pregnancy with a clinical diagnosis of preeclampsia without severe symptoms (P, 38.5 ± 1.4 weeks of pregnancy, n=19), preeclampsia with severe symptoms (SP, 37.5 ± 0.9 weeks of pregnancy, n=22), and normotensive control women (C, 39.1 ± 1.3 weeks of pregnancy, n=20). 10-minutes of abdominal electrocardiograms (ECG) and respiratory signals (RESP) were recorded in all the participants. Subsequently, we obtained the maternal beat-to-beat (RR) and breath-to-breath (BB) time series from ECG and RESP, respectively. The CRC between RR and BB was quantified by nonlinear methods based on information theory, such as MI and RMI, along with the analysis of the novel index of PRQ. Subsequently, we computed the mean PRQ (mPRQ) and the normalized permutation entropy (nPermEn_PRQ) from the PRQ time series generated from BB and RR. In addition, we examined the vagal activity in the three groups by the logarithm of the median of the distribution of the absolute values of successive RR differences (logRSA). ResultsThe MI and RMI values were significantly lower (p<0.05) in the preeclamptic groups compared to the control group. However, no significant differences were found between the preeclamptic groups. The logRSA and nPermEn_PRQ indices were significantly lower (p<0.05) in SP compared to C and P.ConclusionOur data suggest that parturient women with severe and mild preeclampsia may manifest an altered cardiorespiratory coupling compared with normotensive control women. Disrupted CRC in severe preeclampsia could be associated with vagal withdrawal and less complex cardiorespiratory dynamics. The difference in vagal activity between the preeclamptic groups may suggest a further reduction in vagal activity associated with the severity of the disease.

【 授权许可】

Unknown   
Copyright © 2023 Pichardo-Carmona, Reyes-Lagos, Ceballos-Juárez, Ledesma-Ramírez, Mendieta-Zerón, Peña-Castillo, Nsugbe, Porta-García and Mina-Paz