Portal vein thrombosis in cirrhosis: A literature review

Frontiers in Medicine

Medicine

Swathi Prakash¹  Jared Bies¹  Mariam Hassan¹  S. Claudia Didia¹  Adriana Mares² 

[1] Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States;Paul L. Foster School of Medicine, El Paso, TX, United States;

关键词: portal vein;    cirrhosis;    anticoagulation;    thrombosis;    portal hypertension;    bleeding;    rebalanced hemostasis;   

DOI  :  10.3389/fmed.2023.1134801

 received in 2022-12-30, accepted in 2023-03-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Portal Vein Thrombosis (PVT), a common complication of advanced liver disease, is defined as an obstruction of the portal vein due to thrombus formation that can extend to the superior mesenteric and splenic veins. It was believed that PVT occurred predominantly due to prothrombotic potential. However, recent studies have shown that decreased blood flow related to portal hypertension appears to increase PVT risk as per Virchow’s triad. It is well known that there is a higher incidence of PVTs in cirrhosis with a higher MELD and Child Pugh score. The controversy for management of PVTs in cirrhotics lies in the individualized assessment of risks versus benefits of anticoagulation, since these patients have a complex hemostatic profile with both bleeding and procoagulant propensities. In this review, we will systematically compile the etiology, pathophysiology, clinical features, and management of portal vein thrombosis in cirrhosis.

【 授权许可】

Unknown   
Copyright © 2023 Prakash, Bies, Hassan, Mares and Didia.