Childhood Abuse, Social Support, and Long-Term Pharmacological Treatment Outcomes in Patients With Depressive Disorders

Frontiers in Psychiatry

Psychiatry

Ju-Yeon Lee¹  Jae-Min Kim¹  Sung-Wan Kim¹  Ju-Wan Kim¹  Hee-Ju Kang¹  Min Jhon¹  Il-Seon Shin¹  Robert Stewart² 

[1] Department of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea;Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom;South London and Maudsley NHS Foundation Trust, London, United Kingdom;

关键词: depression;    childhood abuse;    social support;    pharmacotherapy;    treatment outcome;   

DOI  :  10.3389/fpsyt.2022.803639

 received in 2021-10-28, accepted in 2022-01-07,  发布年份 2022

来源: Frontiers

【 摘 要 】

ObjectivesThis study was performed to investigate the roles of childhood abuse and social support in predicting short- and long-term pharmacological treatment outcomes in outpatients with depressive disorders in a naturalistic 1-year prospective design.MethodsPatients were recruited at a university hospital in South Korea between March 2012 and April 2017. Subjects with stepwise pharmacotherapy (switching, augmentation, combination, and mixture of these approaches) included 1246 patients at 12-week points in the acute treatment response and 1,015 patients at 12-months in the long-term treatment response. Remission was defined as Hamilton Depression Rating Scale score ≤ 7. Exposure to three types of childhood abuse (physical, emotional, and sexual) before the age of 16 and perceived social support were assessed at baseline.ResultsIndividual associations of childhood abuse were associated with poorer treatment outcomes in the 12-month long-term phase, and no significant individual associations were found for social support level with any period outcome. In combination, any child abuse, emotional abuse, and physical abuse were significantly associated with long-term 12-month remission rate in the presence of higher level of social support after adjustment with significant interaction terms. However, no significant interactions were found with sexual abuse.ConclusionSynergistic interactive effects of child abuse and social support levels on treatment outcomes in depressive patients were found during long-term pharmacotherapy. Thus, depressed patients with a history of childhood abuse may require specialized clinical approaches, including social support, to enhance the long-term treatment outcomes.

【 授权许可】

Unknown   
Copyright © 2022 Lee, Stewart, Kang, Kim, Jhon, Kim, Shin and Kim.