Common microRNA regulated pathways in Alzheimer’s and Parkinson’s disease

Frontiers in Neuroscience

Neuroscience

Adrian C. Williams¹  Benjamin Wright¹  Valentina Di Pietro²  Lisa J. Hill³  Betina Awuson-David³ 

[1] Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom;Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom;School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom;

关键词: microRNA;    neurodegeneration;    Alzheimer’s disease;    Parkinson’s disease;    biomarkers;    therapeutic targets;   

DOI  :  10.3389/fnins.2023.1228927

 received in 2023-06-20, accepted in 2023-08-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation. Recently, miRNA dysregulation has been found in neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The diagnosis of Alzheimer’s and Parkinson’s is currently challenging, mainly occurring when pathology is already present, and although treatments are available for both diseases, the role of treatment is primarily to prevent or delay the progress of the diseases instead of fully overcoming the diseases. Therefore, the challenge in the near future will be to determine effective drugs to tackle the dysregulated biological pathways in neurodegenerative diseases. In the present study, we describe the dysregulation of miRNAs in blood of Alzheimer’s and Parkinson’s patients with the aim to identify common mechanisms between the 2 pathologies and potentially to identify common therapeutic targets which can stop or delay the progression of two most frequent neuropathologies. Two independent systematic reviews, bioinformatic analysis, and experiment validation were performed to identify whether AD and PD share common pathways. A total of 15 common miRNAs were found in the literature and 13 common KEGG pathways. Among the common miRNAs, two were selected for validation in a small cohort of AD and PD patients. Let-7f-5p and miR-29b-3p showed to be good predictors in blood of PD patients.

【 授权许可】

Unknown   
Copyright © 2023 Awuson-David, Williams, Wright, Hill and Di Pietro.