Exosomal circular RNAs: New player in breast cancer progression and therapeutic targets

Frontiers in Genetics

Genetics

Maryam Khayamzadeh¹  Hazha Jamal Hidayat²  Sayran Mohamadtahr³  Bashdar Mahmud Hussen⁴  Soudeh Ghafouri-Fard⁵  Goran Sedeeq Hama Faraj⁶  Elena Jamali⁷  Mohammad Fatih Rasul⁸  Mohammad Taheri⁹  Snur Rasool Abdullah^1,10 

[1] Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Academy of Medical Sciences, Tehran, Iran;Department of Biology, College of Education, Salahaddin University-Erbil, Erbil, Iraq;Department of Medical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq;Department of Medical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq;Center of Research and Strategic Studies, Lebanese French University, Erbil, Iraq;Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Medical Laboratory Science, Komar University of Science and Technology, Sulaimany, Iraq;Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Pharmaceutical Basic Science, Faculty of Pharmacy, Tishk International University, Erbil, Iraq;Institute of Human Genetics, Jena University Hospital, Jena, Germany;Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Medical Laboratory Science, Lebanese French University, Erbil, Iraq;

关键词: breast cancer (BC);    exosome;    circular RNA (circRNA);    exosomal circRNA (exo-circRNA);    therapeutic target;   

DOI  :  10.3389/fgene.2023.1126944

 received in 2022-12-18, accepted in 2023-02-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Breast cancer is the most prevalent type of malignancy among women. Exosomes are extracellular vesicles of cell membrane origin that are released via exocytosis. Their cargo contains lipids, proteins, DNA, and different forms of RNA, including circular RNAs. Circular RNAs are new class of non-coding RNAs with a closed-loop shape involved in several types of cancer, including breast cancer. Exosomes contained a lot of circRNAs which are called exosomal circRNAs. By interfering with several biological pathways, exosomal circRNAs can have either a proliferative or suppressive role in cancer. The involvement of exosomal circRNAs in breast cancer has been studied with consideration to tumor development and progression as well as its effects on therapeutic resistance. However, its exact mechanism is still unclear, and there have not been available clinical implications of exo-circRNAs in breast cancer. Here, we highlight the role of exosomal circRNAs in breast cancer progression and to highlight the most recent development and potential of circRNAas therapeutic targets and diagnostics for breast cancer.

【 授权许可】

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Copyright © 2023 Hussen, Mohamadtahr, Abdullah, Hidayat, Rasul, Hama Faraj, Ghafouri-Fard, Taheri, Khayamzadeh and Jamali.