Low Vitamin D Levels at Birth and Early Respiratory Outcome in Infants With Gestational Age Less Than 29 Weeks

Frontiers in Pediatrics

Pediatrics

Jean-Francois Landrier¹  Vanessa Pauly²  Christophe Buffat³  Honoré Papalia⁴  Anais Samonini⁴  Clotilde des Robert⁴  E. Gras⁴  Farid Boubred⁵ 

[1] Aix-Marseille University, INSERM, INRAE, C2VN, Marseille, France;EA 3279, CEReSS—Health Service Research and Quality of Life Center, Public Health and Medical Information Department, APHM, Marseille, France;Laboratory of Biochemistry and Molecular Biology, Hospital University la Conception, APHM, Marseille, France;Neonatal Unit, Hospital University La Conception, APHM, Marseille, France;Neonatal Unit, Hospital University La Conception, APHM, Marseille, France;Aix-Marseille University, INSERM, INRAE, C2VN, Marseille, France;

关键词: extremely preterm infants;    RDS—respiratory distress syndrome;    surfactant;    vitamin D;    bronchopulmonary dysplasia;    LISA (less invasive surfactant administration);    nasal CPAP (continuous positive airway pressure);    SGA (samll for gestational age);   

DOI  :  10.3389/fped.2021.790839

 received in 2021-10-07, accepted in 2021-11-11,  发布年份 2022

来源: Frontiers

【 摘 要 】

BackgroundVitamin D (VitD) is involved in lung development but its influence on respiratory distress syndrome of extremely preterm (EPT) infants have been little investigated. In this study, we examined the influence of low vitamin D status at birth on early respiratory outcomes of this vulnerable infant population.MethodsCord blood 25(OH)D levels ≤ 75 nmol/L were considered as Low vitamin D levels. Stepwise logistic regression and classification regression-tree analyses were used and the primary outcome was the combined outcome of death or mechanical ventilation need by the end of the first week (death or MV DoL7) as a marker od RDS severity.ResultsThe mean (SD) GA and birth weight were 26 (1.4) weeks and 801 (212) gr, respectively; 81/109 (74%) infants had low 25(OH)D levels. Infants with low VitD levels had 25% higher initial FiO2 levels (p < 0.05) and were more likely to be mechanically ventilated on DoL7 (36 vs. 7%, p < 0.05). Adjusted for gestational age, they had 10-fold higher odds of death or MV DoL7 (p < 0.01). By regression tree analysis, the rate of death or MV DoL7 increased from 18 to 71% in infants with GA < 26 weeks and with cord blood 25(OH)D levels higher and lower than 74 nmol/L, respectively (p < 0.05).ConclusionLow vitamin D levels at birth are associated with early adverse respiratory outcomes in infants with GA less 29 weeks. Further largest studies are needed to confirm this association.

【 授权许可】

Unknown   
Copyright © 2022 Papalia, Samonini, Buffat, Gras, des Robert, Landrier, Pauly and Boubred.