Comparison of the adjuvant effect of conbercept intravitreal injection at different times before vitrectomy for proliferative diabetic retinopathy

Frontiers in Endocrinology

Endocrinology

Zijian Guo¹  Yu Di²  Junjie Ye²  Zhikun Yang²  Weihong Yu² 

[1] Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China;Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China;Key Laboratory of Ocular Fundus Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;

关键词: conbercept;    proliferative diabetic retinopathy;    pars plana vitrectomy;    vascular endothelial growth factor;    adjuvant effect;   

DOI  :  10.3389/fendo.2023.1171628

 received in 2023-02-22, accepted in 2023-05-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeTo assess the optimal time of intravitreal conbercept (IVC) treatment prior to pars plana vitrectomy (PPV) in patients with severe proliferative diabetic retinopathy (PDR).MethodThis study was exploratory in nature. Forty-eight consecutive patients (48 eyes) with PDR were divided into four groups according to different IVC times (0.5 mg/0.05 mL) before PPV: group A (3 days), group B (7 days), group C (14 days), and group D (non-IVC). Intraoperative and postoperative effectiveness were assessed, and vitreous VEGF concentrations were detected.ResultFor intraoperative effectiveness, groups A and D had a higher incidence of intraoperative bleeding than groups B and C (P = 0.041). Furthermore, groups A-C required less surgical time than group D (P < 0.05). For postoperative effectiveness, group B had a significantly higher proportion of visual acuity that improved or remained unchanged than group D (P = 0.014), and groups A-C had lower proportions of postoperative bleeding than group D. The vitreous VEGF concentration of group B (67.04 ± 47.24 pg/mL) was significantly lower than that of group D (178.29 ± 110.50 pg/mL) (P = 0.005).ConclusionIVC treatment that was administered 7 days preoperatively was associated with better effectiveness and a lower vitreous VEGF concentration than its administration at other time points.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Di, Ye, Yu and Guo