Immune responses to Tilapia lake virus infection: what we know and what we don’t know

Frontiers in Immunology

Immunology

Japhette E. Kembou-Ringert¹  Dieter Steinhagen²  Mikolaj Adamek²  Kim D. Thompson³  Janet M. Daly⁴ 

[1] Department of Infection, Immunity and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom;Fish Disease Research Unit, Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany;Moredun Research Institute, Pentlands Science Park, Penicuik, United Kingdom;School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, United Kingdom;

关键词: Tilapia lake virus;    immunity;    innate immunity;    adaptive immunity;    antiviral response;    host immune resistance;    immune subversion;   

DOI  :  10.3389/fimmu.2023.1240094

 received in 2023-06-14, accepted in 2023-07-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tilapia lake virus (TiLV) is a novel contagious pathogen associated with a lethal disease affecting and decimating tilapia populations on several continents across the globe. Fish viral diseases, such as Tilapia lake virus disease (TiLVD), represent a serious threat to tilapia aquaculture. Therefore, a better understanding of the innate immune responses involved in establishing an antiviral state can help shed light on TiLV disease pathogenesis. Moreover, understanding the adaptive immune mechanisms involved in mounting protection against TiLV could greatly assist in the development of vaccination strategies aimed at controlling TiLVD. This review summarizes the current state of knowledge on the immune responses following TiLV infection. After describing the main pathological findings associated with TiLVD, both the innate and adaptive immune responses and mechanisms to TiLV infection are discussed, in both disease infection models and in vitro studies. In addition, our work, highlights research questions, knowledge gaps and research areas in the immunology of TiLV infection where further studies are needed to better understand how disease protection against TiLV is established.

【 授权许可】

Unknown   
Copyright © 2023 Kembou-Ringert, Steinhagen, Thompson, Daly and Adamek