Full-scale numerical simulation of hemodynamics based on left ventricular assist device

Frontiers in Physiology

Physiology

Xinyi Gao¹  Feng He¹  Xiwen Zhang¹  Zhike Xu¹  Chenghan Chen¹  Pengfei Hao² 

[1] Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing, China;Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing, China;Tsinghua University (School of Materials Science and Engineering)—AVIC Aerodynamics Research Institute Joint Research Center for Advanced Materials and Anti-Icing, Beijing, China;

关键词: heart failure;    aorta;    full-scale model;    hemodynamics;    LVAD;    CFD;   

DOI  :  10.3389/fphys.2023.1192610

 received in 2023-03-23, accepted in 2023-05-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

Ventricular assist devices have been widely used and accepted to treat patients with end-stage heart failure. The role of VAD is to improve circulatory dysfunction or temporarily maintain the circulatory status of patients. In order to be closer to the medical practice, a multi-Domain model of the left ventricular coupled axial flow artificial heart was considered to study the effect of its hemodynamics on the aorta. Because whether LVAD itself was connected between the left ventricular apex and the ascending aorta by catheter in the loop was not very important for the analysis of simulation results, on the premise of ensuring the multi-Domain simulation, the simulation data of the import and export ends of LVAD were imported to simplify the model. In this paper, the hemodynamic parameters in the ascending aorta, such as blood flow velocity vector, wall shear stress distribution, vorticity current intensity, vorticity flow generation, etc., have been calculated. The numerical conclusion of this study showed the vorticity intensity under LVAD was significantly higher than that under patients’ conditions and the overall condition is similar to that of a healthy ventricular spin, which can improve heart failure patients’ condition while minimizing other pitfalls. In addition, high velocity blood flow during left ventricular assist surgery is mainly concentrated near the lining of the ascending aorta lumen. What’s more, the paper proposes to use Q criterion to determine the generation of vorticity flow. The Q criterion of LVAD is much higher than that of patients with heart failure, and the closer the LVAD is to the wall of the ascending aorta, the greater the Q criterion is. All these are beneficial to the effectiveness of LVAD in the treatment of heart failure patients and provide clinical suggestions for the LVAD implantation in clinical practice.

【 授权许可】

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Copyright © 2023 Gao, Xu, Chen, Hao, He and Zhang.