Protein arginine methyltransferases in renal development, injury, repair, and fibrosis

Frontiers in Pharmacology

Pharmacology

Georgia Bayliss¹  Jianjun Yu²  Chao Yu²  Shougang Zhuang³ 

[1] Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, United States;Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, United States;

关键词: protein arginine methyltransferases;    methylation;    post-translational modifications;    renal development;    injury;    repair;    kidney;    fibrosis;   

DOI  :  10.3389/fphar.2023.1123415

 received in 2022-12-14, accepted in 2023-01-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

Protein arginine methyltransferases (PRMTs) methylate a range of histone and non-histone substrates and participate in multiple biological processes by regulating gene transcription and post-translational modifications. To date, most studies on PRMTs have focused on their roles in tumors and in the physiological and pathological conditions of other organs. Emerging evidence indicates that PRMTs are expressed in the kidney and contribute to renal development, injury, repair, and fibrosis. In this review, we summarize the role and the mechanisms of PRMTs in regulating these renal processes and provide a perspective for future clinical applications.

【 授权许可】

Unknown   
Copyright © 2023 Yu, Yu, Bayliss and Zhuang.