期刊论文详细信息
Frontiers in Pharmacology
Case report: long-term sustained remission in a case of metastatic colon cancer with high microsatellite instability and KRAS exon 2 p.G12D mutation treated with fruquintinib after local radiotherapy: a case report and literature review
Pharmacology
Ruiqi Wang1  Dan Cong1  Yuansong Bai1  Wenlong Zhang2 
[1] Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, China;null;
关键词: metastatic colon cancer;    microsatellite instability;    KRAS exon 2 p.G12D mutation;    fruquintinib;    radiotherapy;   
DOI  :  10.3389/fphar.2023.1207369
 received in 2023-04-17, accepted in 2023-06-19,  发布年份 2023
来源: Frontiers
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【 摘 要 】

To demonstrate the efficacy of fruquintinib administration after local radiotherapy in a patient with metastatic colon cancer with high microsatellite instability and the KRAS exon 2 p. G12D mutation. The patient was administered four cycles of pembrolizumab intravenous infusion and achieved stable disease as the best outcome. He was then underwent follow-up concurrent radiochemical therapy (local DT4600cGy/23f/32d radiotherapy, and S-1 to increase sensitivity to radiotherapy), but this had little efficacy. Following this, he was administered fruquintinib and achieved sustained partial remission. At the time of last follow-up, the patient was in continuous remission for 30 months. Administration of fruquintinib after local radiotherapy may be an effective treatment for specific populations with metastatic colorectal cancer.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Cong, Bai and Zhang.

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