Frontiers in Pharmacology | |
Case report: long-term sustained remission in a case of metastatic colon cancer with high microsatellite instability and KRAS exon 2 p.G12D mutation treated with fruquintinib after local radiotherapy: a case report and literature review | |
Pharmacology | |
Ruiqi Wang1  Dan Cong1  Yuansong Bai1  Wenlong Zhang2  | |
[1] Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, China;null; | |
关键词: metastatic colon cancer; microsatellite instability; KRAS exon 2 p.G12D mutation; fruquintinib; radiotherapy; | |
DOI : 10.3389/fphar.2023.1207369 | |
received in 2023-04-17, accepted in 2023-06-19, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
To demonstrate the efficacy of fruquintinib administration after local radiotherapy in a patient with metastatic colon cancer with high microsatellite instability and the KRAS exon 2 p. G12D mutation. The patient was administered four cycles of pembrolizumab intravenous infusion and achieved stable disease as the best outcome. He was then underwent follow-up concurrent radiochemical therapy (local DT4600cGy/23f/32d radiotherapy, and S-1 to increase sensitivity to radiotherapy), but this had little efficacy. Following this, he was administered fruquintinib and achieved sustained partial remission. At the time of last follow-up, the patient was in continuous remission for 30 months. Administration of fruquintinib after local radiotherapy may be an effective treatment for specific populations with metastatic colorectal cancer.
【 授权许可】
Unknown
Copyright © 2023 Wang, Cong, Bai and Zhang.
【 预 览 】
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RO202310106915624ZK.pdf | 1718KB | download |