Cellular signaling impacts upon GABAergic cortical interneuron development

Frontiers in Neuroscience

Neuroscience

Emily Ling-Lin Pai¹  April M. Stafford²  Daniel Vogt³ 

[1] Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, United States;Department of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, United States;Department of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, United States;Neuroscience Program, Michigan State University, East Lansing, MI, United States;

关键词: mTOR;    MAPK;    Wnt/beta-catenin;    cortical interneuron;    cellular signaling;   

DOI  :  10.3389/fnins.2023.1138653

 received in 2023-01-12, accepted in 2023-02-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

The development and maturation of cortical GABAergic interneurons has been extensively studied, with much focus on nuclear regulation via transcription factors. While these seminal events are critical for the establishment of interneuron developmental milestones, recent studies on cellular signaling cascades have begun to elucidate some potential contributions of cell signaling during development. Here, we review studies underlying three broad signaling families, mTOR, MAPK, and Wnt/beta-catenin in cortical interneuron development. Notably, each pathway harbors signaling factors that regulate a breadth of interneuron developmental milestones and properties. Together, these events may work in conjunction with transcriptional mechanisms and other events to direct the complex diversity that emerges during cortical interneuron development and maturation.

【 授权许可】

Unknown   
Copyright © 2023 Pai, Stafford and Vogt.