Novel role for non-invasive neuromodulation techniques in central respiratory dysfunction

Frontiers in Neuroscience

Neuroscience

Jiaying Yang¹  Xiaoping Cheng¹  Jun Ni¹  Xinyuan Chen¹  Lan Lv² 

[1] Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China;Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China;Department of Rehabilitation Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China;

关键词: non-invasive neuromodulation techniques;    respiratory dysfunction;    TMS;    tDCS;    central;   

DOI  :  10.3389/fnins.2023.1226660

 received in 2023-05-22, accepted in 2023-08-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Respiration is a crucial steady-state function of human life. Central nervous system injury can damage the central respiratory pattern generator (CRPG) or interrupt its outflow, leading to central respiratory paralysis and dysfunction, which can endanger the patient's life. At present, there is no effective means to reverse this process. Commonly used non-invasive neuromodulation techniques include repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and so forth, which have been widely applied in nervous system diseases and their various secondary symptoms, but rarely in respiratory function. Clinical and animal studies have confirmed that TMS is also suitable for investigating the excitability and plasticity of ascending corticospinal respiratory pathways. In addition, although rTMS and tDCS differ in their respective mechanisms, both can regulate respiratory networks in healthy individuals and in diseased states. In this review, we provide an overview of the physiology of respiration, the use of TMS to assess the excitability of corticophrenic pathways in healthy individuals and in central respiratory disorders, followed by an overview of the animal and clinical studies of rTMS, tDCS and so forth in regulating respiratory circuits and the possible mechanisms behind them. It was found that the supplementary motor area (SMA) and the phrenic motor neuron (PMN) may be key regulatory areas. Finally, the challenges and future research directions of neuroregulation in respiratory function are proposed. Through understanding how neuromodulation affects the respiratory neural circuit non-invasively, we can further explore the therapeutic potential of this neuromodulation strategy, so as to promote the recovery of respiratory function after central nervous system diseases or injury.

【 授权许可】

Unknown   
Copyright © 2023 Lv, Cheng, Yang, Chen and Ni.