Calpain: the regulatory point of myocardial ischemia-reperfusion injury

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Yan-Ting Wang¹  Wan-Li Xie¹  Lu Chen¹  Guo-Yang Liu¹  Qing-Ping Wu¹  Zhen-Zhen Xu¹  Yong Lv¹ 

[1] Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, China;

关键词: programmed cell death;    myocardial ischemia-reperfusion injury;    calpain;    apoptosis;    parthanatos;   

DOI  :  10.3389/fcvm.2023.1194402

 received in 2023-03-27, accepted in 2023-06-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

Calpain is a conserved cysteine protease readily expressed in several mammalian tissues, which is usually activated by Ca2+ and with maximum activity at neutral pH. The activity of calpain is tightly regulated because its aberrant activation will nonspecifically cleave various proteins in cells. Abnormally elevation of Ca2+ promotes the abnormal activation of calpain during myocardial ischemia-reperfusion, resulting in myocardial injury and cardiac dysfunction. In this paper, we mainly reviewed the effects of calpain in various programmed cell death (such as apoptosis, mitochondrial-mediated necrosis, autophagy-dependent cell death, and parthanatos) in myocardial ischemia-reperfusion. In addition, we also discussed the abnormal activation of calpain during myocardial ischemia-reperfusion, the effect of calpain on myocardial repair, and the possible future research directions of calpain.

【 授权许可】

Unknown   
© 2023 Liu, Xie, Wang, Chen, Xu, Lv and Wu.