A quick algorithmic review on management of viral infectious diseases in pediatric solid organ transplant recipients

Frontiers in Pediatrics

Pediatrics

Hosein Alimadadi¹  Hamid Eshaghi²  Marjan Moghadamnia³  Simin Dashti-Khavidaki⁴ 

[1] Department of Gastroenterology, Children’s Medical Center, Tehran University of Medical Science, Tehran, Iran;Department of Infectious Diseases, Pediatrics’ Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;Department of Pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;Department of Pharmacotherapy, Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran;

关键词: pediatrics;    solid organ;    transplantation;    viral infections;    antiviral;   

DOI  :  10.3389/fped.2023.1252495

 received in 2023-07-03, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

Pediatric solid organ transplant is a life-saving procedure for children with end-stage organ failure. Viral infections are a common complication following pediatric solid organ transplantation (SOT), which can lead to increased morbidity and mortality. Pediatric solid organ transplant recipients are at an increased risk of viral infections due to their immunosuppressed state. The most commonly encountered viruses include cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV), varicella-zoster virus (VZV), adenoviruses, and BK polyomavirus. Prevention strategies include vaccination prior to transplantation, post-transplant prophylaxis with antiviral agents, and preemptive therapy. Treatment options vary depending on the virus and may include antiviral therapy and sometimes immunosuppression modification. This review provides a Quick Algorithmic overview of prevention and treatment strategies for viral infectious diseases in pediatric solid organ transplant recipient.

【 授权许可】

Unknown   
© 2023 Moghadamnia, Eshaghi, Alimadadi and Dashti-Khavidaki.