Advances in epigenetic research of adolescent idiopathic scoliosis and congenital scoliosis

Frontiers in Genetics

Genetics

Zihao Ding¹  Duan Sun¹  Yunzhong Cheng¹  Yong Hai² 

[1] Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China;null;

关键词: epigenetics;    biomarkers;    signaling pathways;    adolescent idiopathic scoliosis;    congenital scoliosis;   

DOI  :  10.3389/fgene.2023.1211376

 received in 2023-04-24, accepted in 2023-06-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Scoliosis is a three-dimensional structural deformity of the spine; more than 80% of scoliosis has no specific pathogenesis but is understood to be closely related to genetic, hormonal, and environmental factors. In recent years, the epigenetic alterations observed in scoliosis have been analyzed in numerous studies to determine the pathogenesis and progression of this condition, however, there is currently no comprehensive review of the epigenetic factors to date. We searched PubMed, Embase, and Web of Science databases for relative studies without language and date restrictions in March 2023. Twenty-five studies were included in this review and analyzed from the four main aspects of epigenetic alteration: DNA methylation, non-coding RNAs, histone modifications, and chromatin remodeling. The relationship between DNA methylation, non-coding RNAs, and scoliosis was considerably reported in the literature, and the corresponding related signaling pathways and novel biomarkers observed in scoliosis provide insights into innovative prevention and treatment strategies. However, the role of histone modifications is rarely reported in scoliosis, and few studies have investigated the relationship between scoliosis and chromatin remodeling. Therefore, these related fields need to be further explored to elucidate the overall effects of epigenetics in scoliosis.

【 授权许可】

Unknown   
Copyright © 2023 Sun, Ding, Hai and Cheng.