Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Baonian Liu¹  Shuijin Shao¹  Ziji Cheng¹  Wanting Qin¹  Shaoling Li² 

[1]Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

[2]Department of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China

关键词: biomaker;    circRNA;    doxorubicin;    therapeutic target;    cancer therapy-induced cardiotoxicity;   

DOI  :  10.3389/fcvm.2023.1152436

 received in 2023-01-27, accepted in 2023-03-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cancer therapy-induced cardiotoxicity (CTIC) is an important cause of death in cancer survivors which often results in the withdrawal or discontinuation of drugs. The underlying mechanisms of CTIC remain unclear. Circular RNAs (circRNAs) are a class of non-coding regulatory RNA molecules which have emerged in recent years. They are generated by back splicing and have powerful biological functions, including transcription and splicing, isolating or building macromolecular scaffolds to interfere with microRNA activity and signaling pathways, and acting as templates for translation. Moreover, circRNAs demonstrate high abundance and significant stability. CircRNAs can be used as novel biomarkers because they often function in a cell-type and tissue-specific manner. CircRNAs have attracted increasing attention in cardiovascular disease research, and recent studies exploring the role of circRNAs in CTIC have had promising results. This review will summarize the current understanding of circRNAs’ biogenesis, regulation and function. Their clinical potential as biomarkers, therapeutic agents and drug targets will also be explored.

【 授权许可】

Unknown   
© 2023 Cheng, Qin, Li, Shao and Liu.