Characterization of natural killer and T cells in bronchoalveolar lavage and peripheral blood of sarcoidosis patients

Frontiers in Immunology

Immunology

Genny Del Zotto¹  Emanuela Marcenaro²  Miriana d’Alessandro³  Elena Bargagli³  Laura Bergantini³ 

[1]Department of Research and Diagnostics, IRCCS Istituto Giannina Gaslini, Genova, Italy

[2]Dipartimento di Medicina Sperimentale (DIMES), Università degli Studi di Genova, Genova, Italy

[3]IRCCS Ospedale Policlinico San Martino, Genova, Italy

[4]Respiratory Diseases Unit, Department of Medical Science, Surgery and Neurosciences, University of Siena, Siena, Italy

关键词: sarcoidosis;    bronchoalveolar lavage;    interstitial lung diseases (ILD);    natural killer (NK);    T cells;   

DOI  :  10.3389/fimmu.2022.1080556

 received in 2022-10-26, accepted in 2022-11-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

The characterization of frequency and phenotypes of natural killer (NK) cells and T cells in BAL and peripheral blood of patients with sarcoidosis was evaluated, to discriminate the differential status of these cells in these two compartments. The analysis revealed that CD56brightCD16neg resulted higher in BAL than PB of sarcoidosis and healthy subjects, while CD56dimCD16+ showed a different proportion between BAL and PB of both Sarcoidosis patients and HC. Moreover, in comparison with autologous PB, BAL was characterized by a higher expression of activated NK cell markers NKp44, CD69 and CD25. Significantly increased levels of PD-1+ NK cells in the BAL of patients were detected. Regarding the maturation of CD4 and CD8, an increase of Effector Memory T cells (TEM) was reported in BAL compared to PB. A better characterization of NK and T cells may lead to an improvement of the pathogenetic mechanisms in sarcoidosis.

【 授权许可】

Unknown   
Copyright © 2023 Bergantini, d’Alessandro, Del Zotto, Marcenaro and Bargagli