Global biomarkers of oxidative stress and fractures: a matched case-control study

Frontiers in Endocrinology

Endocrinology

Lisa M. Lix¹  Lijie Feng²  Dingjie Guo²  Shuman Yang³  William D. Leslie⁴  Baoming Yuan⁵  Xianbao Shi⁶ 

[1] Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada;Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China;Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China;Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China;Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada;Department of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin, China;Department of Pharmacy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China;

关键词: oxidative stress;    fluorescent oxidation products;    osteoporosis;    fracture;    Chinese;    hip fractures;    non-hip fractures;    case-control study;   

DOI  :  10.3389/fendo.2023.1179521

 received in 2023-03-04, accepted in 2023-05-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundEvidence for a relationship between oxidative stress and osteoporotic fractures in humans is limited. Fluorescent oxidation products (FlOPs, excitation/emission wavelengths 320/420nm denoted FlOP_320; 360/420nm [FlOP_360]; and 400/475nm [FlOP_400]) are global biomarkers of oxidative stress, and reflect oxidative damage to proteins, phospholipids, and nucleic acids. We investigated the association between FlOPs and a recent osteoporotic fracture.MethodsWe conducted a case-control study in a Chinese population aged 50 years or older. A recent osteoporotic fracture in the cases was confirmed by x-ray. Cases were matched with community-based non-fracture controls (1:2 ratio) for age (± 4 years) and sex. In addition, we conducted a sensitivity unmatched case-control study which included all fracture cases and all eligible non-fracture controls prior to matching. Plasma FlOPs were measured with a fluorescent microplate reader. We used unconditional logistic regression to analyze the association between FlOPs (per 1-SD increase in logarithmic scale) and fracture; odds ratios (OR) and 95% confidence intervals (95% CI) were reported.ResultsForty-four cases and 88 matched controls (mean age: 68.2 years) were included. After covariate adjustment (i.e., body mass index, physical activity, and smoking), higher FlOP_360 (OR = 1.85; 95% CI = 1.03 – 3.34) and FlOP_400 (OR = 13.29; 95% CI = 3.48 – 50.69) levels, but not FlOP_320 (OR = 0.56; 95% CI = 0.27 – 1.15), were associated with increased fracture risk. Subgroup analyses by fracture site and unmatched case-control study found comparable associations of FlOP_360 and FlOP_400 with hip and non-hip fractures.ConclusionsHigher FlOP_360 and FlOP_400 levels were associated with increased risk of fracture, and this association was comparable for hip and non-hip fractures. Prospective studies are warranted to confirm this finding.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Feng, Lix, Leslie, Guo, Shi and Yuan