Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Wan-Hsin Lin¹  Lisa M. Cooper¹  Panos Z. Anastasiadis² 

[1] Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States;null;

关键词: cadherins;    Yap/Taz;    growth factor receptors;    WNT;    Notch;    hedgehog;    epithelial-mesenchymal transition;    immune responses;   

DOI  :  10.3389/fcell.2023.1137013

 received in 2023-01-03, accepted in 2023-05-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to cancer development via alteration of cell-autonomous oncogenic signaling pathways and extrinsic tumor microenvironment. Advances in multiomics have uncovered key signaling events in multiple cancer types, creating a need for a better understanding of the crosstalk between cadherin-catenin complexes and oncogenic pathways. In this review, we focus on the biological functions of classical cadherins and associated catenins, describe how their dysregulation influences major cancer pathways, and discuss feedback regulation mechanisms between cadherin complexes and cellular signaling. We discuss evidence of cross regulation in the following contexts: Hippo-Yap/Taz and receptor tyrosine kinase signaling, key pathways involved in cell proliferation and growth; Wnt, Notch, and hedgehog signaling, key developmental pathways involved in human cancer; as well as TGFβ and the epithelial-to-mesenchymal transition program, an important process for cancer cell plasticity. Moreover, we briefly explore the role of cadherins and catenins in mechanotransduction and the immune tumor microenvironment.

【 授权许可】

Unknown   
Copyright © 2023 Lin, Cooper and Anastasiadis.