Dynapenic abdominal obesity and susceptibility to fall: a prospective analysis of the Osteoarthritis Initiative

Frontiers in Nutrition

Nutrition

Lee Smith¹  Nasser M. Al-Daghri²  Shaun Sabico²  Pinar Soysal³  Mario Barbagallo⁴  Nicola Veronese⁴  Ligia J. Dominguez⁵  Francesco Bolzetta⁶  Ai Koyanagi⁷ 

[1] Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, United Kingdom;Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia;Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey;Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy;Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy;Faculty of Medicine and Surgery, Kore University of Enna, Enna, Italy;Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 "Serenissima", Venice, Italy;Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Barcelona, Spain;ICREA, Barcelona, Spain;

关键词: abdominal obesity;    dynapenia;    dynapenic abdominal obesity;    falls;    older adults;    Osteoarthritis Initiative;   

DOI  :  10.3389/fnut.2023.1153399

 received in 2023-01-29, accepted in 2023-04-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe prediction of the risk of falling remains a challenge in geriatric medicine and the identification of new potential reversible risk factors is a public health priority. In this study, we aim to investigate the association between DAO (dynapenic abdominal obesity) and incident falls in a large sample of people with knee OA (osteoarthritis) or at high risk for this condition, over 8 years of follow-up.MethodsDAO was defined using a waist circumference more than 102 cm in men and 88 cm in women and a concomitant presence of dynapenia, defined as a time over 15 s in the five times chair stands time. Falls, during follow-up, were recorded using self-reported information in the previous year. A logistic binary regression analysis was run, adjusted for potential confounders at the baseline, reporting the data as odds ratios (ORs) with their 95% confidence intervals (CIs).ResultsOverall, 3,844 subjects were included, majority of whom had abdominal obesity. Across the 8 years of follow-up, 2,695 participants fell vs. 1,149 not reporting any fall. Taking those without DAO as reference, the presence of only dynapenia was not associated with risk of falls (OR = 1.18;95%CI: 0.73–1.91; p = 0.50), whilst the presence of abdominal obesity (OR = 1.30; 95%CI: 1.09–1.56; p = 0.004) and DAO (OR = 1.31; 95%CI:1.01–1.73; p = 0.04) were significantly associated with a higher risk of incident falls.ConclusionDAO significantly increased risk of falls as well as the presence of abdominal obesity.

【 授权许可】

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Copyright © 2023 Veronese, Koyanagi, Soysal, Bolzetta, Dominguez, Barbagallo, Sabico, Al-Daghri and Smith.