Behavioral domains in compulsive rats: implications for understanding compulsive spectrum disorders

Frontiers in Behavioral Neuroscience

Behavioral Neuroscience

Santiago Mora¹  Elena Martín-González²  Margarita Moreno-Montoya²  Manuela Olmedo-Córdoba²  Ángeles Prados-Pardo²  Pilar Flores²  Daniel J. Cruz-Garzón² 

[1] Department of Neuroscience and Panum Institute, University of Copenhagen, Copenhagen, Denmark;Department of Psychology and Health Research Centre (CEINSA), University of Almería, Almería, Spain;

关键词: compulsive behavior [F01-145-527-100];    schedule-induced polydipsia;    cognitive control system;    negative valence system;    risky decision-making;    cognitive impulsivity;    behavioral flexibility;    Research Domain Criteria (RDoC);   

DOI  :  10.3389/fnbeh.2023.1175137

 received in 2023-02-27, accepted in 2023-04-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionCompulsive behavior has been proposed as a transdiagnostic trait observed in different neuropsychiatric disorders, such as obsessive-compulsive disorder, autism, and schizophrenia. Research Domain Criteria (RDoC) strategy could help to disentangle the neuropsychological basis of compulsivity for developing new therapeutic and preventive approaches. In preclinical research, the selection of high-drinker (HD) vs. low-drinker (LD) animals by schedule-induced polydipsia (SIP) is considered a putative model of compulsivity, which includes a well-differentiated behavioral pattern.MethodsThe purpose of this research was to assess the cognitive control and the negative valence system domains in a phenotype of compulsive HD rats. After the selection of animals as HD or LD, we assessed behavioral inflexibility by probabilistic spatial reversal learning (PSRL), motor and cognitive impulsivity by variable delay-to-signal (VDS), and risky decision-making by rodent gambling task (rGT).ResultsHD rats performed fewer reversals and showed less probability of pressing the same lever that was previously reinforced on PSRL, more premature responses after the exposure to longer delays on VDS, and more disadvantageous risky choices on rGT. Moreover, HD animals performed more perseverative responses under the punishment period on rGT.DiscussionThese results highlight that HD compulsive phenotype exhibits behavioral inflexibility, insensitivity to positive feedback, waiting impulsivity, risky decision-making, and frustrative non-reward responsiveness. Moreover, these findings demonstrate the importance of mapping different behavioral domains to prevent, treat, and diagnose compulsive spectrum disorders correctly.

【 授权许可】

Unknown   
Copyright © 2023 Martín-González, Olmedo-Córdoba, Prados-Pardo, Cruz-Garzón, Flores, Mora and Moreno-Montoya.