The role of monocytes in thrombotic diseases: a review

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Shuwei Zhou¹  Ke Wang²  Qiaoyin Gou²  Yumeng Lin²  Zhanzhan Wang³  YiJin Cai⁴  Zhongyu Han⁴  Lan Yuan⁴  Qiong Liu⁴  Meiqi Zhang⁴  Luling You⁴  Hongpeng Li⁴  Haoran Chen⁵ 

[1]Department of Radiology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China

[2]Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu, China

[3]Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China

[4]School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China

[5]Science and Education Department, Chengdu Xinhua Hospital, Chengdu, China

关键词: monocyte;    macrophage;    thrombotic diseases;    arterial thrombosis;    intravenous thrombolysis;   

DOI  :  10.3389/fcvm.2023.1113827

 received in 2022-12-01, accepted in 2023-05-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cardiovascular and cerebrovascular diseases are the number one killer threatening people's life and health, among which cardiovascular thrombotic events are the most common. As the cause of particularly serious cardiovascular events, thrombosis can trigger fatal crises such as acute coronary syndrome (myocardial infarction and unstable angina), cerebral infarction and so on. Circulating monocytes are an important part of innate immunity. Their main physiological functions are phagocytosis, removal of injured and senescent cells and their debris, and development into macrophages and dendritic cells. At the same time, they also participate in the pathophysiological processes of pro-coagulation and anticoagulation. According to recent studies, monocytes have been found to play a significant role in thrombosis and thrombotic diseases of the immune system. In this manuscript, we review the relationship between monocyte subsets and cardiovascular thrombotic events and analyze the role of monocytes in arterial thrombosis and their involvement in intravenous thrombolysis. Finally, we summarize the mechanism and therapeutic regimen of monocyte and thrombosis in hypertension, antiphospholipid syndrome, atherosclerosis, rheumatic heart disease, lower extremity deep venous thrombosis, and diabetic nephropathy.

【 授权许可】

Unknown   
© 2023 Han, Liu, Li, Zhang, You, Lin, Wang, Gou, Wang, Zhou, Cai, Yuan and Chen.