Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance

Frontiers in Pediatrics

Pediatrics

Chris Fraser¹  Julia E. Clark²  Emma L. Sweeney³  Kym Lowry³  Jocelyn Hume⁴  David M. Whiley⁴  Adam D. Irwin⁵ 

[1] Blood and Bone Marrow Transplant Program, Queensland Children’s Hospital, Brisbane, QLD, Australia;Infection Management and Prevention Service, Queensland Children’s Hospital, Brisbane, QLD, Australia;The University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia;The University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia;Central Microbiology, Pathology Queensland, Brisbane, QLD, Australia;The University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia;Infection Management and Prevention Service, Queensland Children’s Hospital, Brisbane, QLD, Australia;

关键词: haematopoietic stem cell transplant;    cytomegalovirus;    antiviral resistance;    pediatric;    emerging therapies;   

DOI  :  10.3389/fped.2023.1180392

 received in 2023-03-09, accepted in 2023-05-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cytomegalovirus (CMV) is a ubiquitous virus which causes a mild illness in healthy individuals. In immunocompromised individuals, such as children receiving haematopoietic stem cell transplantation, CMV can reactivate, causing serious disease and increasing the risk of death. CMV can be effectively treated with antiviral drugs, but antiviral resistance is an increasingly common complication. Available therapies are associated with adverse effects such as bone marrow suppression and renal impairment, making the choice of appropriate treatment challenging. New agents are emerging and require evaluation in children to establish their role. This review will discuss established and emerging diagnostic tools and treatment options for CMV, including antiviral resistant CMV, in children undergoing haematopoietic stem cell transplant.

【 授权许可】

Unknown   
© 2023 Hume, Sweeney, Lowry, Fraser, Clark, Whiley and Irwin.