Advanced central nervous system imaging biomarkers in radiologically isolated syndrome: a mini review

Frontiers in Neurology

Neurology

Sara Collorone¹  Michael A. Foster¹  Ahmed T. Toosy² 

[1] Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom;null;

关键词: multiple sclerosis;    magnetic resonance imaging;    optical coherence tomography;    connectivity;    neurodegeneration;    radiologically isolated syndrome;   

DOI  :  10.3389/fneur.2023.1172807

 received in 2023-02-23, accepted in 2023-05-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Radiologically isolated syndrome is characterised by central nervous system white-matter hyperintensities highly suggestive of multiple sclerosis in individuals without a neurological history of clinical demyelinating episodes. It probably represents the pre-symptomatic phase of clinical multiple sclerosis but is poorly understood. This mini review summarises our current knowledge regarding advanced imaging techniques in radiologically isolated syndrome that provide insights into its pathobiology and prognosis. The imaging covered will include magnetic resonance imaging-derived markers of central nervous system volumetrics, connectivity, and the central vein sign, alongside optical coherence tomography-related metrics.

【 授权许可】

Unknown   
Copyright © 2023 Collorone, Foster and Toosy.