Interplay between RNA interference and transposable elements in mammals

Frontiers in Immunology

Immunology

Enzo Z. Poirier¹  Alexis Cornec¹ 

[1] Stem Cell Immunity Team, Institut Curie, PSL Research University, INSERM U932, Paris, France;

关键词: RNA interference;    mammals;    transposable elements;    Dicer (Dicer1);    epigenetics;    pattern recognition receptor (PRR);    pathogen-associated molecular pattern (PAMP);   

DOI  :  10.3389/fimmu.2023.1212086

 received in 2023-04-25, accepted in 2023-06-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

RNA interference (RNAi) plays pleiotropic roles in animal cells, from the post-transcriptional control of gene expression via the production of micro-RNAs, to the inhibition of RNA virus infection. We discuss here the role of RNAi in regulating the expression of self RNAs, and particularly transposable elements (TEs), which are genomic sequences capable of influencing gene expression and disrupting genome architecture. Dicer proteins act as the entry point of the RNAi pathway by detecting and degrading RNA of TE origin, ultimately leading to TE silencing. RNAi similarly targets cellular RNAs such as repeats transcribed from centrosomes. Dicer proteins are thus nucleic acid sensors that recognize self RNA in the form of double-stranded RNA, and trigger a silencing RNA interference response.

【 授权许可】

Unknown   
Copyright © 2023 Cornec and Poirier