A systematic review and meta-analysis of voxel-based morphometric studies of fibromyalgia

Frontiers in Neuroscience

Neuroscience

Shirui Cheng¹  Yuzhu Qu¹  Deliang Zhu²  Ming Xin²  Xingfu Peng² 

[1] Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China;Acupuncture and Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu, China;Geriatric Diseases Institute of Chengdu, Department of Rehabilitation, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, China;

关键词: fibromyalgia;    neuroimaging;    meta-analysis;    signed differential mapping;    voxel-based morphometry;   

DOI  :  10.3389/fnins.2023.1164145

 received in 2023-02-12, accepted in 2023-04-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveAlthough neuroimaging investigations have revealed significant changes in brain structure in fibromyalgia (FM) patients, these findings are inconsistent. The current study conducted a systematic review and meta-analysis of voxel-based morphometric studies in order to comprehend those alterations in brain structure in FM patients.MethodsVoxel-based morphometric (VBM) studies published up to January 17, 2023 were searched in the Web of Science, PubMed, EMBASE, Cochrane Library (CENTRAL), China National Knowledge Infrastructure (CNKI), Chongqing VIP, Wanfang Database. Two independent researchers carried out study screening, quality assessment, clinical data and neuroimaging data extraction. The whole-brain voxel-based gray matter (GM) data of FM patients were collected from eligible studies, and meta-analyzed using anisotropic effect size-signed differential mapping (AES-SDM).ResultsTwelve researches were included in this study, including 289 FM patients (mean age: 47.36 years) and 272 HS (mean age: 47.34 years). According to the meta-analysis, FM patients had increased GM in the right postcentral gyrus and left angular gyrus, and decreased GM in the right cingulate gyrus, right paracingulate gyrus, left cerebellum, and left gyrus rectus.ConclusionOur study suggests that fibromyalgia patients have altered gray matter in several brain regions that are involved in affective, cognitive functions, and in motor adaptations to pain processing.

【 授权许可】

Unknown   
Copyright © 2023 Xin, Qu, Peng, Zhu and Cheng.