Case report: Allogeneic stem cell transplantation for type B insulin resistance

Frontiers in Medicine

Medicine

Anke Tönjes¹  Thomas Ebert¹  Michael Stumvoll¹  Cornelia Gewert²  Robert K. Semple³  Vladan Vucinic⁴  Gerhard Behre⁵  Lorenz Weidhase⁶ 

[1] Medical Department III—Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany;Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;Cambridge Biomedical Research Centre, National Institute for Health Research, Cambridge, United Kingdom;Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom;Cambridge Biomedical Research Centre, National Institute for Health Research, Cambridge, United Kingdom;Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom;University of Leipzig Medical Center, Medical Clinic and Policlinic 1, Hematology, Cellular Therapy and Hemostaseology, Leipzig, Germany;University of Leipzig Medical Center, Medical Clinic and Policlinic 1, Hematology, Cellular Therapy and Hemostaseology, Leipzig, Germany;Clinic for Internal Medicine I, Community Hospital Dessau, Dessau, Germany;University of Leipzig Medical Center, Medical Intensive Care Unit, Leipzig, Germany;

关键词: allogeneic peripheral blood stem cell transplantation;    case report;    rescue therapy;    type B insulin resistance;    Wiskott-Aldrich syndrome;    diabetes;   

DOI  :  10.3389/fmed.2023.1200037

 received in 2023-04-04, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

Type B insulin resistance (TBIR) is a rare, often fulminant form of insulin resistance caused by autoantibodies against the insulin receptor. If left untreated, its mortality is high. Various immunosuppressive regimens have shown efficacy, but treatment effects are variable and time-delayed, and drug-induced complications may arise. We report a patient with TBIR arising as a complication of Wiskott–Aldrich syndrome. Stable remission of TBIR was achieved through allogeneic peripheral blood stem cell transplantation (PBSCT) over a follow-up period of more than 1.5 years. We thus demonstrate that PBSCT can be considered a treatment option in TBIR where conventional immunosuppressive therapy is ineffective or contraindicated.

【 授权许可】

Unknown   
Copyright © 2023 Ebert, Behre, Weidhase, Vucinic, Gewert, Semple, Stumvoll and Tönjes.