MRI-based porosity index (PI) and suppression ratio (SR) in the tibial cortex show significant differences between normal, osteopenic, and osteoporotic female subjects

Frontiers in Endocrinology

Endocrinology

Gina Woods¹  Dina Moazamian²  Sophia Dwek²  Jiyo Athertya²  Jiang Du³  Christine B. Chung³  Hyungseok Jang³  Eric Y. Chang³  Yajun Ma³  Saeed Jerban⁴ 

[1] Department of Medicine, University of California, San Diego, CA, United States;Department of Radiology, University of California, San Diego, CA, United States;Department of Radiology, University of California, San Diego, CA, United States;Radiology Service, Department of Research, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States;Department of Radiology, University of California, San Diego, CA, United States;Radiology Service, Department of Research, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States;Department of Orthopaedic Surgery, University of California, San Diego, CA, United States;

关键词: osteoporosis;    cortical bone;    MRI;    ultrashort echo time (UTE);    bone quality;   

DOI  :  10.3389/fendo.2023.1148345

 received in 2023-01-20, accepted in 2023-03-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionUltrashort echo time (UTE) MRI enables quantitative assessment of cortical bone. The signal ratio in dual-echo UTE imaging, known as porosity index (PI), as well as the signal ratio between UTE and inversion recovery UTE (IR-UTE) imaging, known as the suppression ratio (SR), are two rapid UTE-based bone evaluation techniques developed to reduce the time demand and cost in future clinical studies. The goal of this study was to investigate the performance of PI and SR in detecting bone quality differences between subjects with osteoporosis (OPo), osteopenia (OPe), and normal bone (Normal).MethodsTibial midshaft of fourteen OPe (72 ± 6 years old), thirty-one OPo (72 ± 6 years old), and thirty-seven Normal (36 ± 19 years old) subjects were scanned using dual-echo UTE and IR-UTE sequences on a clinical 3T scanner. Measured PI, SR, and bone thickness were compared between OPo, OPe, and normal bone (Normal) subjects using the Kruskal–Wallis test by ranks. Spearman’s rank correlation coefficients were calculated between dual-energy x-ray absorptiometry (DEXA) T-score and UTE-MRI results.ResultsPI was significantly higher in the OPo group compared with the Normal (24.1%) and OPe (16.3%) groups. SR was significantly higher in the OPo group compared with the Normal (41.5%) and OPe (21.8%) groups. SR differences between the OPe and Normal groups were also statistically significant (16.2%). Cortical bone was significantly thinner in the OPo group compared with the Normal (22.0%) and OPe (13.0%) groups. DEXA T-scores in subjects were significantly correlated with PI (R=-0.32), SR (R=-0.50), and bone thickness (R=0.51).DiscussionPI and SR, as rapid UTE-MRI-based techniques, may be useful tools to detect and monitor bone quality changes, in addition to bone morphology, in individuals affected by osteoporosis.

【 授权许可】

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Copyright © 2023 Jerban, Ma, Moazamian, Athertya, Dwek, Jang, Woods, Chung, Chang and Du