Mechanisms of tumor-associated macrophages affecting the progression of hepatocellular carcinoma

Frontiers in Pharmacology

Pharmacology

Da-Yong Zheng¹  Ying Cui²  Dailin Wu³  Zhenjie Zhuang³  Tianqi Gao³  Dan Huang³  Yan Zhao³  Yi Yuan³  Jing Li³  Ying Tang⁴ 

[1] Department of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;Department of Hepatology, TCM-Integrated Hospital of Southern Medical University, Guangzhou, Guangdong, China;Department of Hepatopancreatobiliary, Cancer Center, Southern Medical University, Guangzhou, Guangdong, China;Department of Psychiatry, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China;Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China;

关键词: hepatocellular carcinoma;    tumor-associated macrophages;    tumor microenvironment;    cancer stem cells;    carcinoma cell proliferation;    invasion and migration;    angiogenesis;    hepatic fibrosis;   

DOI  :  10.3389/fphar.2023.1217400

 received in 2023-05-05, accepted in 2023-06-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tumor-associated macrophages (TAMs) are essential components of the immune cell stroma of hepatocellular carcinoma. TAMs originate from monocytic myeloid-derived suppressor cells, peripheral blood monocytes, and kupffer cells. The recruitment of monocytes to the HCC tumor microenvironment is facilitated by various factors, leading to their differentiation into TAMs with unique phenotypes. TAMs can directly activate or inhibit the nuclear factor-κB, interleukin-6/signal transducer and signal transducer and activator of transcription 3, Wnt/β-catenin, transforming growth factor-β1/bone morphogenetic protein, and extracellular signal-regulated kinase 1/2 signaling pathways in tumor cells and interact with other immune cells via producing cytokines and extracellular vesicles, thus affecting carcinoma cell proliferation, invasive and migratory, angiogenesis, liver fibrosis progression, and other processes to participate in different stages of tumor progression. In recent years, TAMs have received much attention as a prospective treatment target for HCC. This review describes the origin and characteristics of TAMs and their mechanism of action in the occurrence and development of HCC to offer a theoretical foundation for further clinical research of TAMs.

【 授权许可】

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Copyright © 2023 Yuan, Wu, Li, Huang, Zhao, Gao, Zhuang, Cui, Zheng and Tang.