Regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract and MRI research progress: a literature review

Frontiers in Neuroscience

Neuroscience

Jun Xiong¹  Tianning Sun²  Hongbing Xiang²  Zhigang He²  Maohui Feng³  Anne Manyande⁴ 

[1] Center for Liver Transplantation, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;Department of Gastrointestinal Surgery, Wuhan Peritoneal Cancer Clinical Medical Research Center, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, Hubei, China;School of Human and Social Sciences, University of West London, London, United Kingdom;

关键词: cognitive impairment;    liver disease;    humoral factor;    MRI research;    brain;   

DOI  :  10.3389/fnins.2023.1206417

 received in 2023-04-15, accepted in 2023-05-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Patients with liver disease are prone to various cognitive impairments. It is undeniable that cognitive impairment is often regulated by both the nervous system and the immune system. In this review our research focused on the regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract, and revealed that its mechanisms may be involved with hyperammonemia, neuroinflammation, brain energy and neurotransmitter metabolic disorders, and liver-derived factors. In addition, we share the emerging research progress in magnetic resonance imaging techniques of the brain during mild cognitive impairment associated with liver disease, in order to provide ideas for the prevention and treatment of mild cognitive impairment in liver disease.

【 授权许可】

Unknown   
Copyright © 2023 Sun, Feng, Manyande, Xiang, Xiong and He.