CBT4CBT web-based add-on treatment for cocaine use disorder: Study protocol for a randomized controlled trial

Frontiers in Psychiatry

Psychiatry

Mercè Madre¹  Francesca Batlle¹  Joan Trujols²  Santiago Duran-Sindreu²  Alba Palazón-Llecha³  Núria Mallorquí-Bagué³ 

[1] Addictive Behaviors Unit, Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;Addictive Behaviors Unit, Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain;Addictive Behaviors Unit, Department of Psychiatry, Biomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;Department of Psychology, University of Girona, Girona, Spain;

关键词: cocaine use disorder;    treatment;    cognitive behavioral therapy;    treatment outcome;    gender;    predictive factors;    clinical trial;    protocol;   

DOI  :  10.3389/fpsyt.2023.1051528

 received in 2022-09-22, accepted in 2023-02-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundCocaine use disorder (CUD) is a chronic condition that presents high relapse rates and treatment dropouts. Web-based interventions have proven to be effective when optimizing face-to-face treatments in different mental health conditions and have the potential to optimize current CUD treatments. However, web-based interventions in addictive behaviors are still limited. The aim of this study is to evaluate whether adding a web-based cognitive behavioral therapy (i.e., CBT4CBT) to standard CUD treatment, improves treatment outcomes in a Spanish sample of patients with severe CUD (which requires inpatient treatment). Additionally, we aim to explore predictive factors of treatment response and treatment gender-related differences.MethodsAll individuals coming for inpatient cocaine detoxification who meet the inclusion criteria will have the possibility to be part of the study. The participants of this open-label randomized controlled clinical trial (RCT) will be allocated to treatment as usual (TAU) or TAU+CBT4CBT after the hospitalization for cocaine detoxification. During the inpatient treatment they will all receive an individualized psychological intervention. There will be six time point assessments: at 48–72 h of starting inpatient treatment, at the end of inpatient treatment and before starting day care and outpatient treatment, at the end of the 8 weeks CTB4CBT / TAU arm treatment and at three follow-up time points (1-, 3-, and 6-months post-treatment).DiscussionTo the best of our knowledge, this is the first RCT that explores the efficacy of adding a web-based cognitive behavioral therapy to usual CUD treatment with patients of a clinical sample in Europe.Trial registrationIIBSP-CTB-2020-116, NCT05207228. Submitted 8th of April 2021, posted 26 st of January 2022. https://clinicaltrials.gov/ct2/show/NCT05207228?cond=Cocaine+Use+Disorder&draw=2&rank=1.

【 授权许可】

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Copyright © 2023 Mallorquí-Bagué, Palazón-Llecha, Madre, Batlle, Duran-Sindreu and Trujols.