Association between sarcopenia and kidney stones in United States adult population between 2011 and 2018

Frontiers in Nutrition

Nutrition

Changbao Xu¹  Tao Zhang²  Huajuan Shi²  Jinliang Ni³  Keyi Wang³  Yifan Zhang³  Changxiu Tian³  Wei Song³  Houliang Zhang³  Yidi Wang³  Bo Peng⁴ 

[1] Department of Urology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Urology, Shanghai Putuo District People’s Hospital, Tongji University, Shanghai, China;Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;Department of Urology, Shanghai Putuo District People’s Hospital, Tongji University, Shanghai, China;

关键词: sarcopenia;    sarcopenia index;    kidney stones;    cross-section study;    NHANES;   

DOI  :  10.3389/fnut.2023.1123588

 received in 2022-12-14, accepted in 2023-02-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeTo investigate the relationship between kidney stones and sarcopenia in United States adult population between 2011 and 2018.Materials and methodsWe conducted a cross-section study based on the National Health and Nutrition Examination Survey (NHANES) including 39,156 individuals. Sarcopenia was assessed by the sarcopenia index. Association between kidney stones and sarcopenia verified by multiple logistic regression analysis and dose–response curves analysis using restricted cubic spline (RCS) regression. Meanwhile, propensity score matching (PSM) was performed to exclude the effect of confounding variables.ResultsThere were 9,472 participants in the study by our accurate enrollment screening process. The odds of kidney stones decreased significantly with the increase of sarcopenia index. Logistic regression analysis showed that sarcopenia expressed significant differences in the participants which suffered kidney stone before PSM (p < 0.001). In model 4, adjusting all relevant covariates shown that adjusted odds ratio (aOR) of the 95% confidence intervals for kidney stones in all participants, age <39 years and age ≥40 years, were, respectively, 1.286 (1.006–1,643), 1.697 (1.065–2.702), and 0.965 (0.700–1.330) for sarcopenia, and p values were 0.044, 0.026, and 0.827. After performing PSM, the aOR of the 95% in modal 4 for kidney stones in all participants and age <40 year were 2.365 (1.598–3.500) and 6.793 (2.619–17.6180), respectively (p < 0.01), and especially the aOR in participants (age ≥40) was 1.771(1.138–2.757) with p value being 0.011.ConclusionSarcopenia was positively related to the potential risk of kidney stones in the United States adult population.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Zhang, Tian, Wang, Ni, Song, Shi, Zhang, Xu, Wang and Peng.