Lack of functional brain connectivity was associated with poor inhibition in children with attention-deficit/hyperactivity disorder using near-infrared spectroscopy

Frontiers in Psychiatry

Psychiatry

Shaohua Wang¹  Longfei Cao²  Xinyu He³  Guannan Bai³  Yusang Dong³  Wenjing Liao⁴  Rongwang Yang⁴  Lingli Leng⁵ 

[1] Affiliated Mental Health Center, Zhejiang University School of Medicine (Hangzhou Seventh People’s Hospital), Hangzhou, China;Centre for Cognition and Brain Disorders, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China;Department of Child Health Care, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China;Department of Psychology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China;Department of Sociology, Zhejiang University, Hangzhou, China;

关键词: attention deficit hyperactivity disorder;    brain;    functional connection;    inhibition function;    near-infrared spectroscopy;    children;   

DOI  :  10.3389/fpsyt.2023.1221242

 received in 2023-05-12, accepted in 2023-06-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesThe present study aimed to evaluate the characteristics of functional brain connectivity in the resting state in children with attention deficit hyperactivity disorder (ADHD) and to assess the association between the connectivity and inhibition function using near-infrared spectroscopy (NIRS).MethodsIn total, 34 children aged 6–13 diagnosed with ADHD were recruited from Hangzhou Seventh People’s Hospital. In comparison, 37 healthy children were recruited from a local primary school as controls matched by age and sex. We used NIRS to collect information on brain images. The Stroop test assessed inhibition function. We compared the differences in functional brain connectivity in two groups by analyzing the resting-state brain network. Pearson partial correlation analysis was applied to evaluate the correlation between functional brain connectivity and inhibition in all the children.ResultsCompared with the control group, results of NIRS images analysis showed that children with ADHD had significantly low functional brain connectivity in regions of the orbitofrontal cortex, left dorsolateral prefrontal cortex, left pre-motor and supplementary motor cortex, inferior prefrontal gyrus, and right middle temporal gyrus (p = 0.006). Inhibition function of children with ADHD was negatively correlated with functional brain connectivity (p = 0.009), while such correlation was not found in the control group.ConclusionThe present study demonstrated that children with ADHD had relatively low connectivity in several brain regions measured at the resting state. Our results supported the evidence that lack of functional brain connectivity was associated with impaired inhibition function in children with ADHD.

【 授权许可】

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Copyright © 2023 Liao, Cao, Leng, Wang, He, Dong, Yang and Bai.