Renal K+ retention in physiological circumstances: focus on adaptation of the distal nephron and cross-talk with Na+ transport systems

Frontiers in Physiology

Physiology

Samia Lasaad¹  Gilles Crambert¹ 

[1] Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université Paris Cité, Laboratoire de Physiologie Rénale et Tubulopathies, Paris, France;CNRS EMR 8228—Unité Métabolisme et Physiologie Rénale, Paris, France;

关键词: potassium balance;    ATP12A;    blood pressure;    sodium balance;    extracellular compartment;   

DOI  :  10.3389/fphys.2023.1264296

 received in 2023-07-20, accepted in 2023-08-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Consumption of salt (NaCl) and potassium (K+) has been completely modified, switching from a rich-K+/low-NaCl diet in the hunter–gatherer population to the opposite in the modern, westernized population. The ability to conserve K+ is crucial to maintain the plasma K+ concentration in a physiological range when dietary K+ intake is decreased. Moreover, a chronic reduction in the K+ intake is correlated with an increased blood pressure, an effect worsened by a high-Na+ diet. The renal adaptation to a low-K+ diet in order to maintain the plasma K+ level in the normal range is complex and interconnected with the mechanisms of the Na+ balance. In this short review, we will recapitulate the general mechanisms allowing the plasma K+ value to remain in the normal range, when there is a necessity to retain K+ (response to low-K+ diet and adaptation to gestation), by focusing on the processes occurring in the most distal part of the nephron. We will particularly outline the mechanisms of K+ reabsorption and discuss the consequences of its absence on the Na+ transport systems and the regulation of the extracellular compartment volume and blood pressure.

【 授权许可】

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Copyright © 2023 Lasaad and Crambert.