Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Frontiers in Immunology

Immunology

Jianwen Mo¹  Tianting Guo²  Jiacheng Ma³  Dongwen Wu³  Chucun Fang³  Mengting Yao³  Zilong Wang³ 

[1] Department of Orthopedic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;Department of Orthopedics, Guangdong Provincial People’s Hospital Ganzhou Hospital, Ganzhou Municipal Hospital, Ganzhou, Jiangxi, China;The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China;Department of Orthopedic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;

关键词: deep venous thrombosis;    neutrophil;    neutrophil extracellular traps;    platelet;    deoxyribonuclease;   

DOI  :  10.3389/fimmu.2023.1198952

 received in 2023-04-02, accepted in 2023-08-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically manifests as swelling and pain in the lower limbs. The most serious clinical complication of DVT is pulmonary embolism (PE), which has a high mortality rate. To date, its underlying mechanisms are not fully understood, and patients usually present with clinical symptoms only after the formation of the thrombus. Thus, it is essential to understand the underlying mechanisms of deep vein thrombosis for an early diagnosis and treatment of DVT. In recent years, many studies have concluded that Neutrophil Extracellular Traps (NETs) are closely associated with DVT. These are released by neutrophils and, in addition to trapping pathogens, can mediate the formation of deep vein thrombi, thereby blocking blood vessels and leading to the development of disease. Therefore, this paper describes the occurrence and development of NETs and discusses the mechanism of action of NETs on deep vein thrombosis. It aims to provide a direction for improved diagnosis and treatment of deep vein thrombosis in the near future.

【 授权许可】

Unknown   
Copyright © 2023 Yao, Ma, Wu, Fang, Wang, Guo and Mo