Omega-3 intake is associated with liver disease protection

Frontiers in Public Health

Public Health

Kate Townsend Creasy¹  Eleonora Scorletti²  Katharina Sophie Seeling³  Leonida Hehl³  Kai Markus Schneider³  Mara Sophie Vell³  Miriam Daphne Rendel³  Carolin Victoria Schneider⁴ 

[1] Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, United States;Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Department of Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany;Department of Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany;Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;The Institute for Translational Medicine and Therapeutics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;

关键词: Omega-3 fatty acids;    NAFLD;    liver disease;    primary prevention;    alcoholic liver disease (ALD);   

DOI  :  10.3389/fpubh.2023.1192099

 received in 2023-03-22, accepted in 2023-07-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundNon-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease are among the most common liver diseases worldwide, and there are currently no Food and Drug Administration (FDA)-approved treatments. Recent studies have focused on lifestyle changes to prevent and treat NAFLD. Omega-3 supplementation is associated with improved outcomes in patients with chronic liver disease. However, it is unclear whether Omega-3 supplementation can prevent the development of liver disease, particularly in individuals at an increased (genetic) risk.MethodsIn this UK Biobank cohort study, we established a multivariate cox proportional hazards model for the risk of incident liver disease during an 11 year follow up time. We adjusted the model for diabetes, prevalent cardiovascular disorders, socioeconomic status, diet, alcohol consumption, physical activity, medication intake (insulin, biguanides, statins and aspirin), and baseline characteristics.ResultsOmega-3 supplementation reduced the risk of incident liver disease (HR = 0.716; 95% CI: 0.639, 0.802; p = 7.6 × 10−9). This protective association was particularly evident for alcoholic liver disease (HR = 0.559; 95% CI: 0.347, 0.833; p = 4.3 × 10−3), liver failure (HR = 0.548; 95% CI: 0.343, 0.875; p = 1.2 × 10−2), and non-alcoholic liver disease (HR = 0.784; 95% CI: 0.650, 0.944; p = 1.0 × 10−2). Interestingly, we were able to replicate the association with reduced risk of NAFLD in a subset with liver MRIs (HR = 0.846; 95% CI: 0.777, 0.921; p = 1.1 × 10−4). In particular, women benefited from Omega-3 supplementation as well as heterozygous allele carriers of the liver-damaging variant PNPLA3 rs738409.ConclusionsOmega-3 supplementation may reduce the incidence of liver disease. Our study highlights the potential of personalized treatment strategies for individuals at risk of metabolic liver disease. Further evaluation in clinical trials is warranted before Omega-3 can be recommended for the prevention of liver disease.

【 授权许可】

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Copyright © 2023 Vell, Creasy, Scorletti, Seeling, Hehl, Rendel, Schneider and Schneider.