Molecular crosstalk between circadian clock and cancer and therapeutic implications

Frontiers in Nutrition

Nutrition

Meng Qu¹ 

[1] null;

关键词: circadian rhythm;    cancer;    clock-targeting;    chronomedicine;    chronotherapy;   

DOI  :  10.3389/fnut.2023.1143001

 received in 2023-01-12, accepted in 2023-02-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

The circadian clock governs activity of many physiological processes, thereby playing a pivotal role in human health. Circadian disruption is closely associated with cancer development; in particular, recent discoveries have provided strong evidence supporting specific functions of different molecular clock components in either promoting or inhibiting tumorigenesis. This narrative review aims to summarize the existing data on molecular connections between the clock and cancer. These results along with future efforts pave the road to targeting the circadian clock as a novel pathway for therapeutic intervention. Given the implications of chrono-nutrition interventions such as time-restricted feeding in extending lifespan, chrono-nutrition may have preventive and therapeutic applications for individuals with and at-risk of age-related diseases including cancer.

【 授权许可】

Unknown   
Copyright © 2023 Qu.