Comparative effect of antihypertensive drugs in improving arterial stiffness in adults with hypertension (RIGIPREV study). A network meta-analysis

Frontiers in Pharmacology

Pharmacology

Rosa Maria Bruno¹  Leticia Gómez-Sánchez²  Manuel Ángel Gómez-Marcos³  Cristina Lugones-Sánchez³  Luis García-Ortiz³  José Francisco López-Gil⁴  Iván Cavero-Redondo⁵  Alicia Saz-Lara⁶  Diana P. Pozuelo-Carrascosa⁶ 

[1] Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;INSERM U970, Paris Cardiovascular Research Center (PARCC), Université de Paris, Hopital Europeen Georges Pompidou—APHP, Paris, France;Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile;Health and Social Research Center, Universidad de Castilla- La Mancha, Cuenca, Spain;INSERM U970, Paris Cardiovascular Research Center (PARCC), Université de Paris, Hopital Europeen Georges Pompidou—APHP, Paris, France;

关键词: antihypertensive drugs;    hypertension;    arterial stiffness;    pulse wave velocity;    augmentation index;   

DOI  :  10.3389/fphar.2023.1225795

 received in 2023-05-22, accepted in 2023-08-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Aims: To synthesize and evaluate the available scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension by using a network meta-analysis approach.Methods: A systematic search of the MEDLINE (via PubMed), Scopus, and Web of Science databases was conducted to identify experimental studies addressing the effect of different antihypertensive drugs on arterial stiffness parameters (pulse wave velocity [PWV] and augmentation index [AIx]) in adults with hypertension. Comparative evaluation of the effect of antihypertensive drugs was performed by conducting a standard pairwise meta-analysis and a network meta-analysis for direct and indirect comparisons between antihypertensive drugs and placebo/other antihypertensive drugs. Analyses were performed including studies of any duration and only studies longer than 6 months length.Results: Seventy-six studies were included in the main analysis and considering only studies longer than 6 months length, thiazide diuretics, ACEIs, ARBs, the ACEI/ARB combination, the ACEI/CCB combination, and the ARB/CCB combination showed a higher effect on reducing PWV, and ACEIs and ARBs on reducing AIx.Conclusion: Our research provides evidence that antihypertensive medications are an effective way to treat arterial stiffness in adults with hypertension. Based on our findings, patients with hypertension who have greater levels of arterial stiffness may benefit from using thiazide diuretics, ACEIs, ARBs, the ACEI/ARB combination, the ACEI/CCB combination, and the ARB/CCB combination.Systematic Review Registration: PROSPERO (CRD42021276360).

【 授权许可】

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Copyright © 2023 Cavero-Redondo, Saz-Lara, Lugones-Sánchez, Pozuelo-Carrascosa, Gómez-Sánchez, López-Gil, García-Ortiz, Bruno and Gómez-Marcos.