Genetic and epigenetic background of diabetic kidney disease

Frontiers in Endocrinology

Endocrinology

Niina Sandholm¹  Emma H. Dahlström¹  Per-Henrik Groop² 

[1] Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland;Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland;Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland;Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland;Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia;

关键词: diabetic kidney disease;    kidney failure;    GWAS;    genome sequencing;    exome sequencing;    epigenetics;    epigenome-wide association study;    EWAS;   

DOI  :  10.3389/fendo.2023.1163001

 received in 2023-02-10, accepted in 2023-05-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD, but DKD is a complex multifactorial disease, which takes years to develop. Family studies have shown that inherited factors also contribute to the risk of the disease. During the last decade, genome-wide association studies (GWASs) have emerged as a powerful tool to identify genetic risk factors for DKD. In recent years, the GWASs have acquired larger number of participants, leading to increased statistical power to detect more genetic risk factors. In addition, whole-exome and whole-genome sequencing studies are emerging, aiming to identify rare genetic risk factors for DKD, as well as epigenome-wide association studies, investigating DNA methylation in relation to DKD. This article aims to review the identified genetic and epigenetic risk factors for DKD.

【 授权许可】

Unknown   
Copyright © 2023 Sandholm, Dahlström and Groop