First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke

Frontiers in Neuroscience

Neuroscience

Wolfgang Wick¹  Martin Bendszus²  Arne Potreck²  Angelika Hoffmann³  Tanja Platt⁴  Fabian J. Kratzer⁴  Sebastian C. Niesporek⁴  Armin M. Nagel⁵  Myriam Keymling⁶  Heinz-Peter Schlemmer⁶  Daniel Paech⁷  Louise Ebersberger⁸  Mark E. Ladd⁹ 

[1] Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany;Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany;Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany;Department of Neuroradiology, Bern University Hospital, Bern, Switzerland;Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany;Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany;Institute of Radiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen University Hospital, Erlangen, Germany;Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany;Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany;Department of Neuroradiology, Bonn University Hospital, Bonn, Germany;Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany;Faculty of Medicine, University of Heidelberg, Heidelberg, Germany;Faculty of Medicine, University of Heidelberg, Heidelberg, Germany;Faculty of Medicine, University of Heidelberg, Heidelberg, Germany;Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany;Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany;

关键词: oxygen-17 MRI;    stroke;    metabolic imaging;    ultra-high field;    7 Tesla;    oxygen metabolism;   

DOI  :  10.3389/fnins.2023.1186558

 received in 2023-03-14, accepted in 2023-05-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Dynamic oxygen-17 (17O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this investigation was the first application of dynamic 17O MRI at 7 Tesla (T) in a patient with stroke. In this proof-of-concept experiment, dynamic 17O MRI was applied during 17O inhalation in a patient with early subacute stroke. The analysis of the relative 17O water (H217O) signal for the affected stroke region compared to the healthy contralateral side revealed no significant difference. However, the technical feasibility of 17O MRI has been demonstrated paving the way for future investigations in neurovascular diseases.

【 授权许可】

Unknown   
Copyright © 2023 Ebersberger, Kratzer, Potreck, Niesporek, Keymling, Nagel, Bendszus, Wick, Ladd, Schlemmer, Hoffmann, Platt and Paech.