Risk factors and a prediction model for unruptured intracranial aneurysms in patients with ischemic stroke using carotid intima-media thickness and systemic atherosclerosis

Frontiers in Neurology

Neurology

Yanyu Wu¹  Xueyang He²  Zhixian Jiang²  Gaiming Gao²  Jinning Zhang²  Dezhi Kang³ 

[1] Department of Anesthesiology, First Hospital of Quanzhou, Quanzhou, Fujian, China;Department of Neurosurgery, First Hospital of Quanzhou, Quanzhou, Fujian, China;Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China;

关键词: carotid intima-media thickness;    unruptured intracranial aneurysms;    systemic atherosclerosis;    ischemic stroke;    risk factors;    prediction model;   

DOI  :  10.3389/fneur.2023.1227673

 received in 2023-05-23, accepted in 2023-07-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundSystemic atherosclerosis and carotid intima-media thickness (IMT) have been widely used in clinical practice for ischemic stroke; however, little is known about the risk factors for unruptured intracranial aneurysms (UIAs) in patients with ischemic stroke (IS). Therefore, we performed this study to identify the risk factors and construct a prediction model for UIA in patients with IS.MethodsData were retrospectively collected from patients with IS from 2015 to 2022 at the First Hospital of Quanzhou City, Quanzhou, Fujian, China. Risk factors for UIA in patients with IS were identified using a multivariate logistic regression model, and a receiver operating characteristic (ROC) curve was applied to construct the prediction model.ResultsOut of the 122 patients with IS, 52 who presented with UIA (ISUIA) were categorized into the study group and the remaining 70 IS patients without UIA into the control group. Patients in the ISUIA group had lower carotid IMT and carotid artery plaque scores than those in the IS group (P < 0.05). Multivariate analyses found that aspirin use (OR: 12.987; P = 0.031), elevated C-reactive protein (CRP) level (OR: 1.019; P = 0.004), and carotid IMT > 0.09 mm (OR: 0.218; P < 0.001) were significantly associated with the risk of UIA in patients with IS. However, UIA in patients with IS was unaffected by the carotid artery plaque score (P = 0.114). The constricted prediction model based on the abovementioned factors for UIA in IS patients was 0.79 (95% CI: 0.71–0.87).ConclusionThe findings revealed that the risk factors for UIA in patients with IS included aspirin use, elevated CRP level, and smaller carotid IMT, and the predictive value of the prediction model was relatively better.

【 授权许可】

Unknown   
Copyright © 2023 Gao, Kang, Zhang, Jiang, He and Wu.