The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

Frontiers in Oncology

Oncology

Rong He¹  Lian He¹  Zhe Dai¹  Chang-Feng Man¹  Yu Fan¹  Lin Yao¹  Jia-Bin Huang¹  Shou-Yan Xiang¹  Xiao-Yan Wang² 

[1] Cancer Institute, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China;Digestive Department, The Affiliated Suqian first People’s Hospital of Nanjing Medical University, Suqian, China;

关键词: mA modification;    non-coding RNAs (ncRNAs);    gastrointestinal tract cancers;    colorectal cancer;    long non-coding RNA (lncRNA);   

DOI  :  10.3389/fonc.2021.784127

 received in 2021-09-27, accepted in 2021-12-15,  发布年份 2022

来源: Frontiers

【 摘 要 】

N6-methyladenosine (m6A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m6A modification process by affecting the expression of m6A-related enzymes. The interaction between m6A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m6A and non-coding RNAs in gastrointestinal tract cancers.

【 授权许可】

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Copyright © 2021 Yao, Man, He, He, Huang, Xiang, Dai, Wang and Fan