Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Dan Li¹  Jiali Nie¹  Yu Han¹  Li Ni² 

[1] Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China;null;

关键词: atrial fibrillation;    epigenetic regulation;    DNA methylation;    histone modification;    non-coding RNAs;   

DOI  :  10.3389/fcvm.2021.763824

 received in 2021-08-24, accepted in 2021-12-08,  发布年份 2022

来源: Frontiers

【 摘 要 】

Atrial fibrillation (AF) is the most common arrhythmia attacking 1. 5–2.0% of general population worldwide. It has a significant impact on morbidity and mortality globally and its prevalence increases exponentially with age. Therapies like catheter ablation or conventional antiarrhythmic drugs have not provided effective solution to the recurrence for AF over the past decades. Over 100 genetic loci have been discovered to be associated with AF by Genome-wide association studies (GWAS) but none has led to a therapy. Recently potential involvement of epigenetics (DNA methylation, histone modification, and non-coding RNAs) in the initiation and maintenance of AF has partly emerged as proof-of-concept in the mechanism and management of AF. Here we reviewed the epigenetic features involved in AF pathophysiology and provided an update of their implications in AF therapy.

【 授权许可】

Unknown   
Copyright © 2022 Li, Nie, Han and Ni.