Effects of body mass index and insulin resistance on first-time assisted conception and perinatal outcomes in young polycystic ovary syndrome patients

Frontiers in Endocrinology

Endocrinology

Jiayu Guo¹  Yilin Jiang¹  Cuilian Zhang¹  Yuanhui Chen¹ 

[1]Reproductive Medical Center, People’s Hospital of Zhengzhou University, Zhengzhou, China

[2]Reproductive Medical Center, Henan Provincial People’s Hospital, Zhengzhou, China

关键词: insulin resistance;    polycystic ovary syndrome;    overweight;    early pregnancy loss rate;    multivariate logistic regression analysis;   

DOI  :  10.3389/fendo.2023.1170816

 received in 2023-02-21, accepted in 2023-07-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThe objective of the study was to explore the effect of body mass index (BMI) and insulin resistance (IR) levels on first-time assisted conception results and perinatal outcomes in young polycystic ovary syndrome (PCOS) patients.DesignThis was a single-center, retrospective, observational cohort study.PatientsYoung women with PCOS undergoing their first embryo transfer were included in the study.Main outcome measureEarly pregnancy loss rate was the main outcome measure.ResultsThe early pregnancy loss rate in the overweight + insulin resistance group (OW+IR group) was significantly higher than that in the non-overweight + non-insulin resistance group (NOW+NIR group) (18.16% vs. 9.02%, Bonferroni correction, P = 0.012). The early pregnancy loss rate in the non-overweight + insulin resistance group (NOW+IR group) and overweight + non-insulin resistance group (OW+NIR group) (18.18% and 17.14%, respectively) were also higher than that in the NOW+NIR group (6.07%), but the difference was not statistically significant (Bonferroni correction, all P > 0.05). No significant difference was found in clinical pregnancy rate, live birth rate, and macrosomia rate (all P > 0.05). After adjusting for confounding factors, BMI and IR levels were identified as independent risk factors for early pregnancy loss rate.ConclusionBMI and IR levels are independent risk factors for early pregnancy loss in young PCOS patients during the first embryo transfer cycle. Multiple indicators should be considered when assessing pregnancy outcomes, which will promote individualized pregnancy guidance and treatment procedures for PCOS patients.

【 授权许可】

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Copyright © 2023 Guo, Chen, Jiang and Zhang