Abnormal spontaneous brain activity in females with autism spectrum disorders

Frontiers in Neuroscience

Neuroscience

Ge Zhang¹  Weidong Zhang¹  Yu Shen¹  Wei Wei¹  Yan Bai¹  Xinhui Wang¹  Jiapei Xie²  Nan Meng²  Xipeng Yue²  Meiyun Wang³  Xianchang Zhang⁴ 

[1] Department of Medical Imaging, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Zhengzhou, China;Department of Medical Imaging, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Zhengzhou, China;Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China;Department of Medical Imaging, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Zhengzhou, China;Laboratory of Brain Science and Brain-Like Intelligence Technology, Institute for Integrated Medical Science and Engineering, Henan Academy of Sciences, Zhengzhou, China;MR Collaboration, Siemens Healthineers Ltd., Beijing, China;

关键词: autism spectrum disorders;    amplitude of low-frequency fluctuation;    fractional amplitude of low-frequency fluctuation;    regional homogeneity;    spontaneous brain activity;   

DOI  :  10.3389/fnins.2023.1189087

 received in 2023-03-18, accepted in 2023-05-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesTo date, most studies on autism spectrum disorder (ASD) have focused on sample sets that were primarily or entirely composed of males; brain spontaneous activity changes in females remain unclear. The purpose of this study was to explore changes in the brain spontaneous neural activity in females with ASD.MethodsIn this study, resting-state functional magnetic resonance images (rs-fMRI) of 41 females with ASD and 41 typically developing (TD) controls were obtained from the ABDIE database. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) of the two groups were calculated to detect the regional brain activity. A two independent sample t-test was used to analyze differences between the ASD and TD groups and a p-value <0.05 was considered statistically significant after false discovery rate (FDR) correction. Pearson correlation analysis was conducted between social responsiveness scale (SRS) scores and the local activity of significantly different brain regions.ResultsCompared with the typically developing (TD) group, the values of ALFF and ReHo were significantly increased in the left superior temporal gyrus (STG), while the values of ReHo were significantly decreased in the left superior frontal gyrus (SFG), left middle occipital gyrus (MOG), bilateral superior parietal lobule (SPL), and bilateral precuneus in the females with ASD group. Correlation analysis showed that the ReHo of the right precuneus was positively correlated to the total SRS, social communication, and autistic mannerisms.ConclusionSpontaneous activity changes in females with ASD involved multiple brain regions and were related to clinical characteristics. Our results may provide some help for further exploring the neurobiological mechanism of females with ASD.

【 授权许可】

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Copyright © 2023 Xie, Zhang, Shen, Wei, Bai, Zhang, Meng, Yue, Wang, Zhang and Wang.