Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent

Frontiers in Pharmacology

Pharmacology

William N. Setzer¹  Priyanka Sati²  Ahmad Faizal Abdull Razis³  Javad Sharifi-Rad⁴  Vijay Laxmi Trivedi⁵  Praveen Dhyani⁶  Silvia Tejada⁷  Antoni Sureda⁸  Babagana Modu⁹  Ruchi Soni^1,10  Monica Butnariu^1,11 

[1] Aromatic Plant Research Center, Lehi, UT, United States;Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, United States;Department of Biotechnology, Kumaun University, Bhimtal, Uttarakhand, India;Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia;Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia;Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador;High Altitude Plant Physiology Research Centre (HAPPRC), HNB. Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand, India;Institute for Integrated Natural Sciences, University of Koblenz, Koblenz, Germany;Laboratory of Neurophysiology, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain;Health Research Institute of Balearic Islands (IdISBa), Palma de Mallorca, Spain;CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain;Laboratory of Neurophysiology, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain;Health Research Institute of Balearic Islands (IdISBa), Palma de Mallorca, Spain;Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands—IUNICS, Palma de Mallorca, Spain;Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia;Department of Biochemistry, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria;Regional Centre for Organic and Natural Farming, Ghaziabad, Uttar Pradesh, India;University of Life Sciences “King Mihai I” From Timisoara, Timis, Romania;

关键词: Boswellia;    cancer;    bioactive compounds;    apoptosis;    triterpenes;   

DOI  :  10.3389/fphar.2023.1187181

 received in 2023-03-15, accepted in 2023-07-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

With the advent of highly effective plant-based medications with few or no side effects, the use of phytomedicines against complex diseases such as cancer is becoming more widespread. The broadly recognized pentacyclic triterpenes known as boswellic acids (BAs) are derived from the oleogum resin, or frankincense, extracted from the plant species of the genus Boswellia. The frankincense mixture contains various BA types, each having a different potential and helping treat certain cancers. This review focuses on details regarding the traits of the BAs, their roles as anti-cancer agents, the mechanism underlying their activities, and the function of their semi-synthetic derivatives in managing and treating certain cancers. The review also explores the biological sources of BAs, how they are conserved, and how biotechnology might help preserve and improve in vitro BA production. The review concludes that the BAs and their semi-synthetic derivatives are effective against a broad spectrum of cancer cell lines. The detailed information in the review can be helpful for researchers to gain more information about BAs and BA-based medications for efficient and cost-effective cancer treatments.

【 授权许可】

Unknown   
Copyright © 2023 Trivedi, Soni, Dhyani, Sati, Tejada, Sureda, Setzer, Faizal Abdull Razis, Modu, Butnariu and Sharifi-Rad.